Understanding Depression

Depression and the Salience Network

Salience isn’t just our namesake. It’s also the name of the network in the brain that is most correlated with depression. The word “Salience” means “prominence or deserving of our attention,” which perfectly describes the Salience Network and its role in deciding how mood and thoughts are focused.

As the brain’s emotional control center, the Salience Network delivers signals to and from the areas of the brain that determine how we act, react and respond to situations, thoughts and feelings. When a person is suffering from Major Depressive Disorder, often the signals that would normally regulate mood and emotions cannot make their way back across the Salience Network. Many patients with depression also experience other symptoms such as anxiety or lack of sleep due to this lack of connectivity.

Our FDA cleared, non-invasive TMS treatment helps awaken and strengthen those neural networks through repetition and stimulation. Similar to the concept of physical therapy, Salience TMS therapy works to restore the brain’s ability to naturally decode, evaluate and react to what’s happening around it, helping patients truly recover from depression and reconnect back to their life.

We started Salience TMS Neuro Solutions because mental health is deserving of our community’s attention. Since then, we’ve made it our mission to deliver TMS treatment with the respect and care that all people suffering from depression deserve.

What is Major Depressive Disorder?

Major Depressive Disorder is a common and serious medical illness that causes persistent and distressing symptoms that negatively affect your ability to regulate your thoughts, behaviors and emotions. It can lead to a variety of emotional and physical problems, making it difficult for a person to function at work and at home. When left unchecked, depression weakens or disconnects neural pathways in the Salience Network.

clinical depression treatment - major depressive disorder – MDD therapy Dallas Plano Fort Worth – Salience TMS Neuro Solutions
clinical depression treatment - major depressive disorder – MDD therapy Dallas Plano Fort Worth – Salience TMS Neuro Solutions

How TMS Reconnects the Salience Network.

TMS uses MRI strength pulses field to safely and systematically target, stimulate and strengthen disengaged neural pathways. Over time, the inactive synapses begin firing again, connecting the proper signals back to the Salience Network—and reconnecting patients back to life.

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What Causes Depression?

While we don’t know the root cause of depression, research indicates that trauma, hormonal imbalances, genetic inheritance and physical changes in the brain all play a role. Changes in brain chemistry or function may affect the neurotransmitters and the interaction of neural pathways along the Salience Network that regulate mood and determine how you think, feel, act and react. When these neural networks aren’t connecting as they should, mood disorders like depression can occur.

What Does Depression Feel Like?

When you’re depressed, everything that you once held as important begins to fade. You begin to disconnect from the world around you. Your job. Your family. Your entire life. Depression can lead to a variety of emotional and physical problems, making it difficult for a person to function at work and at home, including:

  • Feelings of hopelessness, extreme guilt or worthlessness.
  • Loss of interest, apathy or social isolation.
  • Trouble concentrating, making decisions, or memory loss.
  • Significant weight gain or loss.
  • Fatigue and lack of concentration.
  • Physical aches or pain.
  • Anxiety, angry outbursts, or frustration.
  • Suicidal thinking or thoughts of death.
clinical depression treatment - major depressive disorder – MDD therapy Dallas Plano Fort Worth – Salience TMS Neuro Solutions
Request a appointment and get connected.

TMS is a safe, FDA-cleared, non-invasive treatment that takes about a half hour per session. With over 150,000 treatments performed and an over 70% positive response rate, TMS can be the answer when medications have failed.

clinical depression treatment - major depressive disorder – MDD therapy Dallas Plano Fort Worth – Salience TMS Neuro Solutions

Supporting Someone With Depression

When someone you love has depression, you can feel disconnected from the person you know in your heart. Dealing with any chronic illness leaves friends, family, and loved ones frustrated and angry, especially when medications and treatments don’t lead to true recovery.

Together, with patients and supportive loved ones, Salience creates a customized TMS treatment plan and navigates complex insurance issues to make the path to wellness simple and easy. Our highly trained team and patient advocates have a uniquely better and proven approach to treatment. Helping someone live again is one of the greatest acts of love and kindness. There are a few ways you can help make the connection:


  • Start a conversation and get educated about depression treatment options, like medication, therapy or TMS treatments.
  • Encourage them to take the first step. It’s often the hardest part, and with your help, it can be easier.
  • Don’t blame or stigmatize your loved one. Depression is a chronic illness with difficult and complex symptoms.
  • Remember that depression is a recognized medical condition that can only be recovered from with professional help.
  • Advocate for and support your loved one throughout their treatment process. Listen and open conversations along the way.